JAK1 Antikörper (pTyr1022)

Produktnummer ABIN196868

Produktdetails anti-JAK1 Antikörper

Target: JAK1 (Janus Kinase 1 (JAK1))

Bindungsspezifität: pTyr1022

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site. JAK1 (phospho-Tyr1022) antibody detects endogenous levels of JAK1 only when phosphorylated at tyrosine 1022.

Aufreinigung: Immunoaffinity chromatography.

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human JAK1 around the phosphorylation site of tyrosine 1022 (K-E-YP-Y-T).

Anwendungsinformationen

Applikationshinweise: Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Referenzen für anti-JAK1 Antikörper (ABIN196868)

Fetter, Smith, Guel, Braegelmann, Bieber, Wenzel: "Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions." in: Frontiers in immunology, Vol. 11, pp. 344, (2021) (PubMed).

Details zu JAK1

Target: JAK1 (Janus Kinase 1 (JAK1))

Andere Bezeichnung: Tyrosine-Protein Kinase JAK1 (JAK1 Produkte)

Synonyme: JAK1A antikoerper, JAK1B antikoerper, JTK3 antikoerper, AA960307 antikoerper, C130039L05Rik antikoerper, wu:fb93e10 antikoerper, jak1 antikoerper, Janus kinase 1 antikoerper, tyrosine-protein kinase JAK1 antikoerper, JAK1 antikoerper, Jak1 antikoerper, jak1 antikoerper, LOC100286690 antikoerper

Hintergrund: Synonyms: JAK-1, JAK1A, JAK1B, Janus kinase 1

Gen-ID: 3716

NCBI Accession: NP_002218

UniProt: P23458

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response