BCL10 Antikörper (AA 1-143)

Produktnummer ABIN1944800

Der Maus Monoklonal Anti-BCL10-Antikörper wurde für WB, FACS und IHC (p) validiert. Er ist geeignet, BCL10 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für BCL10 Antikörper (AA 1-143) (ABIN1944800)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCL10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1185CT13-2-1-2

Produktdetails anti-BCL10 Antikörper

Bindungsspezifität: AA 1-143

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This BCL10 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-143 amino acids from the human region of human BCL10.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-BCL10 Antikörper (ABIN1944800)

Koseki, Inohara, Chen, Carrio, Merino, Hottiger, Nabel, Núñez: "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 9955-61, (1999) (PubMed).

Thome, Martinon, Hofmann, Rubio, Steiner, Schneider, Mattmann, Tschopp: "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 9962-8, (1999) (PubMed).

Yan, Lee, Schilbach, Goddard, Dixit: "mE10, a novel caspase recruitment domain-containing proapoptotic molecule." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 10287-92, (1999) (PubMed).

Details zu BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Andere Bezeichnung: BCL10

Hintergrund: Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

Molekulargewicht: 26252

Gen-ID: 8915

UniProt: O95999

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine