Retinoblastoma Binding Protein 8 Antikörper (AA 452-747)

Produktnummer ABIN1886481

Der Kaninchen Polyklonal anti-Retinoblastoma Binding Protein 8 Antikörper (ABIN1886481) detektiert spezifisch Retinoblastoma Binding Protein 8 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (AA 452-747) (ABIN1886481)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper

Bindungsspezifität: AA 452-747

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 452 and 747 of CtIP

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: CtIP

Hintergrund: The protein encoded by this gene is a ubiquitously expressed nuclear protein.It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation.This protein complexes with transcriptional co-repressor CTBP.It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1.Three transcript variants encoding two different isoforms have been found for this gene.More transcript variants exist, but their full-length natures have not been determined.[provided by RefSeq]

Molekulargewicht: 102 kDa

Gen-ID: 5932

NCBI Accession: NM_002894, NP_002885

Pathways: Zellzyklus, DNA Reparatur