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Src Antikörper (N-Term)

Name: Src Antikörper (N-Term)
SKU: ABIN1881833
Price: 434.77 EUR
Availability: InStock

Der Kaninchen Polyklonal Anti-Src-Antikörper wurde für WB, IF, IHC (p) und FACS validiert. Er ist geeignet, Src in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

SRC Antibody (N-term) A western blot analysis in MCF-7,A431 cell line lysates (35 μg/lane). (Src Antikörper (N-Term))

SRC Antibody (N-term) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram). (Src Antikörper (N-Term))

FACS

Confocal immunofluorescent analysis of SRC Antibody (N-term) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Src Antikörper (N-Term))

Confocal immunofluorescent analysis of SRC Antibody (N-term) with A431 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Src Antikörper (N-Term))

SRC Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human small intestine tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. (Src Antikörper (N-Term))

IHC (p)

SRC Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. (Src Antikörper (N-Term))

IHC (p)

6 Abbildungen

(5 Referenzen)

Produktnummer ABIN1881833

Datenblatt (PDF)

Kurzübersicht für Src Antikörper (N-Term) (ABIN1881833)

Target

Alle Src Antikörper anzeigen

Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reaktivität

Human

Wirt

Kaninchen

Klonalität

Polyklonal

Konjugat

Dieser Src Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon

RB41141

Bindungsspezifität
25

24

20

20

16

15

15

11

10

8

7

6

5

4

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 24-52, N-Term

Homologie

M

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This SRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human SRC.

Isotyp

IgG
anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
Src Reaktivität: Human, Maus WB, IF Wirt: Maus Monoclonal 17AT28 unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
Src Reaktivität: Human WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 1F11 unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 1-80) antibody
Src Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr530) antibody
Src Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
KO Validated Src Reaktivität: Human WB, IF, IP Wirt: Kaninchen Monoclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 24-52) antibody
Src Reaktivität: Human WB, ELISA, IHC, IF, FACS Wirt: Kaninchen Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 397-424) antibody
Src Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr529) antibody
Src Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 397-424) antibody
Src Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB21492 unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 1-90) antibody
Src Reaktivität: Human WB, ELISA, IF, IHC (p), PLA Wirt: Maus Monoclonal 1B9 unconjugated

Applikationshinweise

IF: 1:50. IF: 1:50. WB: 1:2000. IHC-P: 1:50. IHC-P: 1:50. FC: 1:50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Haltbarkeit

6 months
Kieslinger, Hiechinger, Dobreva, Consalez, Grosschedl: "Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner." in: Cell stem cell, Vol. 7, Issue 4, pp. 496-507, (2010) (PubMed).

Pradhan, Alrehani, Patel, Khatlani, Vijayan: "Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29059-68, (2010) (PubMed).

Dergai, Tsyba, Dergai, Zlatskii, Skrypkina, Kovalenko, Rynditch: "Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface." in: Biochemical and biophysical research communications, Vol. 399, Issue 2, pp. 307-12, (2010) (PubMed).

Liu, Qiu, Li, Chen, Cao et al.: "Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via ..." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 21934-42, (2010) (PubMed).

Pene-Dumitrescu, Smithgall: "Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21446-57, (2010) (PubMed).
Target

Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Andere Bezeichnung

SRC

Substanzklasse

Viral Protein

Hintergrund

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Molekulargewicht

59835

NCBI Accession

NP_005408, NP_938033

UniProt

P12931

Pathways

JAK-STAT Signalweg, Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling