SDHB Antikörper (C-Term)

Produktnummer ABIN1881781

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SDHB in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für SDHB Antikörper (C-Term) (ABIN1881781)

Target: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SDHB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41925

Produktdetails anti-SDHB Antikörper

Bindungsspezifität: AA 205-234, C-Term

Homologie: B, M, Pig

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SDHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SDHB Antikörper (ABIN1881781)

Ho, Morrison, Silva, Coomber: "The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression." in: Bioscience reports, Vol. 36, Issue 1, pp. e00299, (2016) (PubMed).

Boominathan, Vanhoozer, Basisty, Powers, Crampton, Wang, Friedricks, Schilling, Brand, OConnor: "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant." in: Nucleic acids research, Vol. 44, Issue 19, pp. 9342-9357, (2016) (PubMed).

Cerecer-Gil, Figuera, Llamas, Lara, Escamilla, Ramos, Estrada, Hussain, Gaal, Korpershoek, de Krijger, Dinjens, Devilee, Bayley: "Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 16, pp. 4148-54, (2010) (PubMed).

Hes, Weiss, Woortman, de Miranda, van Bunderen, Bonsing, Stokkel, Morreau, Romijn, Jansen, Vriends, Bayley, Corssmit: "Low penetrance of a SDHB mutation in a large Dutch paraganglioma family." in: BMC medical genetics, Vol. 11, pp. 92, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Details zu SDHB

Target: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Andere Bezeichnung: SDHB

Hintergrund: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Molekulargewicht: 31630

NCBI Accession: NP_002991

UniProt: P21912