PARP1 Antikörper (pSer373)

Produktnummer ABIN1881626

Produktdetails anti-PARP1 Antikörper

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Bindungsspezifität: pSer373

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP1 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This rat PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S373 of rat PARP1.

Klon: RB40136

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PARP1 Antikörper (ABIN1881626)

Beneke, Scherr, Ponath, Popp, Bürkle: "Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span." in: Mechanisms of ageing and development, Vol. 131, Issue 5, pp. 366-9, (2010) (PubMed).

Kondo, Obitsu, Ohta, Matsunami, Otsuka, Teshima: "Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13079-91, (2010) (PubMed).

Zaalishvili, Margiani, Kutalia, Suladze, Zaalishvili: "Automodification of PARP-1 mediates its tight binding to the nuclear matrix." in: Biochemical and biophysical research communications, Vol. 393, Issue 1, pp. 123-5, (2010) (PubMed).

Drel, Xu, Zhang, Pavlov, Shevalye, Slusher, Obrosova: "Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy." in: Endocrinology, Vol. 150, Issue 12, pp. 5273-83, (2009) (PubMed).

Adamczyk, Kaźmierczak: "Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway." in: Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences, Vol. 47, Issue 3, pp. 247-51, (2009) (PubMed).

Details zu PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Andere Bezeichnung: PARP1 (PARP1 Produkte)

Synonyme: ADPRT antikoerper, ADPRT 1 antikoerper, ADPRT1 antikoerper, ARTD1 antikoerper, PARP antikoerper, PARP-1 antikoerper, PPOL antikoerper, pADPRT-1 antikoerper, Adprt antikoerper, Parp-1 antikoerper, 5830444G22Rik antikoerper, AI893648 antikoerper, Adprp antikoerper, Adprt1 antikoerper, C80510 antikoerper, parp-1 antikoerper, sPARP-1 antikoerper, BEST:LD21673 antikoerper, CG17685 antikoerper, CG17696 antikoerper, CG17718 antikoerper, CG40411 antikoerper, D.PARP antikoerper, Dm.pARTa antikoerper, Dmel\\CG40411 antikoerper, LD21673.3prime antikoerper, PARP1 antikoerper, dPARP antikoerper, parp antikoerper, adprt1 antikoerper, padprt-1 antikoerper, ppol antikoerper, si:dkey-206f10.3 antikoerper, wu:fc60f12 antikoerper, zgc:110092 antikoerper, poly(ADP-ribose) polymerase 1 antikoerper, poly (ADP-ribose) polymerase 1 antikoerper, poly (ADP-ribose) polymerase family, member 1 antikoerper, Poly-(ADP-ribose) polymerase antikoerper, poly(ADP-ribose) polymerase 1 L homeolog antikoerper, PARP1 antikoerper, Parp1 antikoerper, Parp antikoerper, parp1.L antikoerper, parp1 antikoerper

Hintergrund: Catalyzes poly (ADP-ribose) protein modification, plays a role in DNA repair and genome stability [RGD].

Molekulargewicht: 112660

NCBI Accession: NP_037195

UniProt: P27008

Pathways: Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location