PARP1 Antikörper (pSer373)

Produktnummer ABIN1881626

Der Kaninchen Polyklonal Anti-PARP1-Antikörper wurde für DB validiert. Er ist geeignet, PARP1 in Proben von Ratte zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für PARP1 Antikörper (pSer373) (ABIN1881626)

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP1 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB40136

Produktdetails anti-PARP1 Antikörper

Bindungsspezifität: pSer373

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This rat PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S373 of rat PARP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PARP1 Antikörper (ABIN1881626)

Beneke, Scherr, Ponath, Popp, Bürkle: "Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span." in: Mechanisms of ageing and development, Vol. 131, Issue 5, pp. 366-9, (2010) (PubMed).

Kondo, Obitsu, Ohta, Matsunami, Otsuka, Teshima: "Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13079-91, (2010) (PubMed).

Zaalishvili, Margiani, Kutalia, Suladze, Zaalishvili: "Automodification of PARP-1 mediates its tight binding to the nuclear matrix." in: Biochemical and biophysical research communications, Vol. 393, Issue 1, pp. 123-5, (2010) (PubMed).

Drel, Xu, Zhang, Pavlov, Shevalye, Slusher, Obrosova: "Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy." in: Endocrinology, Vol. 150, Issue 12, pp. 5273-83, (2009) (PubMed).

Adamczyk, Kaźmierczak: "Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway." in: Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences, Vol. 47, Issue 3, pp. 247-51, (2009) (PubMed).

Details zu PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Andere Bezeichnung: PARP1

Hintergrund: Catalyzes poly (ADP-ribose) protein modification, plays a role in DNA repair and genome stability [RGD].

Molekulargewicht: 112660

NCBI Accession: NP_037195

UniProt: P27008

Pathways: Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location