CDKN1B Antikörper (pThr197)

Produktnummer ABIN1881619

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CDKN1B in DB. Er zeigt eine Reaktivität gegenüber Maus und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für CDKN1B Antikörper (pThr197) (ABIN1881619)

Target: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN1B Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB42131

Produktdetails anti-CDKN1B Antikörper

Bindungsspezifität: pThr197

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This mouse p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T197 of mouse p27Kip1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CDKN1B Antikörper (ABIN1881619)

Singh, Jatzek, Plisch, Srinivasan, Svaren, Suresh: "Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1." in: Molecular and cellular biology, Vol. 30, Issue 21, pp. 5145-59, (2010) (PubMed).

Antico-Arciuch, Dima, Liao, Refetoff, Di Cristofano: "Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females." in: Oncogene, Vol. 29, Issue 42, pp. 5678-86, (2010) (PubMed).

Mitsuhashi, Yonemoto, Sone, Kosuge, Kosaki, Takahashi: "In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 37, pp. 16331-5, (2010) (PubMed).

Zhang, Li, Yuan, Tian, Weidenfeld, Yang, Liu, Chokas, Morrisey: "Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms." in: Genes & development, Vol. 24, Issue 16, pp. 1746-57, (2010) (PubMed).

Wang, Li, Jiao, Zhang, Shao, Yuan, Yu: "RNA interference reveals a requirement for both p18INK4c and p27Kip1 in B lymphopoiesis." in: Journal of molecular cell biology, Vol. 2, Issue 4, pp. 209-16, (2010) (PubMed).

Details zu CDKN1B

Target: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Andere Bezeichnung: p27Kip1

Hintergrund: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Molekulargewicht: 22193

NCBI Accession: NP_034005

UniProt: P46414

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagie