c-MET Antikörper

Produktnummer ABIN1881539

Der Kaninchen Polyklonal Anti-c-MET-Antikörper wurde für WB validiert. Er ist geeignet, c-MET in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für c-MET Antikörper (ABIN1881539)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-MET Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB17704

Produktdetails anti-c-MET Antikörper

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZNF593 antibody is generated from rabbits immunized with a His fusion protein from human MET.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-c-MET Antikörper (ABIN1881539)

Holgren, Dougherty, Edwin, Cerasi, Taylor, Fichera, Joseph, Bissonnette, Khare: "Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas." in: Oncogene, Vol. 29, Issue 38, pp. 5241-53, (2010) (PubMed).

Song, Li, Tretiakova, Salgia, Cagle, Husain: "Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung." in: Archives of pathology & laboratory medicine, Vol. 134, Issue 11, pp. 1702-5, (2010) (PubMed).

Thanseem, Nakamura, Miyachi, Toyota, Yamada, Tsujii, Tsuchiya, Anitha, Iwayama, Yamada, Hattori, Matsuzaki, Matsumoto, Iwata, Suzuki, Suda, Kawai, Sugihara, Takebayashi, Takei, Ichikawa, Sugiyama et al.: "Further evidence for the role of MET in autism susceptibility. ..." in: Neuroscience research, Vol. 68, Issue 2, pp. 137-41, (2010) (PubMed).

Sugiura, Kawaguchi, Soejima, Katsumata, Gono, Baba, Kawamoto, Murakawa, Yamanaka, Hara: "Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis patients: beneficial roles of HGF in muscle regeneration." in: Clinical immunology (Orlando, Fla.), Vol. 136, Issue 3, pp. 387-99, (2010) (PubMed).

Tyner, Fletcher, Wang, Yang, Rutenberg-Schoenberg, Beadling, Mori, Heinrich, Deininger, Druker, Loriaux: "MET receptor sequence variants R970C and T992I lack transforming capacity." in: Cancer research, Vol. 70, Issue 15, pp. 6233-7, (2010) (PubMed).

Details zu c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung: MET

Hintergrund: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 155541

NCBI Accession: NP_000236, NP_001120972

UniProt: P08581

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor