Cyclin D3 Antikörper (pSer264)

Produktnummer ABIN1881180

Dieses Anti-Cyclin D3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin D3 in DB. Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für Cyclin D3 Antikörper (pSer264) (ABIN1881180)

Target: Cyclin D3 (CCND3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D3 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB42160

Produktdetails anti-Cyclin D3 Antikörper

Bindungsspezifität: pSer264

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCND3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S264 of human CCND3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Cyclin D3 Antikörper (ABIN1881180)

Kim, Kim, Ko: "CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression." in: Cytokine, Vol. 50, Issue 1, pp. 42-9, (2010) (PubMed).

Gumina, Xu, Chiles: "Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E." in: Cell cycle (Georgetown, Tex.), Vol. 9, Issue 4, pp. 820-8, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Kamatani, Matsuda, Okada, Kubo, Hosono, Daigo, Nakamura, Kamatani: "Genome-wide association study of hematological and biochemical traits in a Japanese population." in: Nature genetics, Vol. 42, Issue 3, pp. 210-5, (2010) (PubMed).

Details zu Cyclin D3

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: CCND3

Hintergrund: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 32520

NCBI Accession: NP_001129489, NP_001129597, NP_001129598, NP_001751

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process