CHEK1 Antikörper (AA 1-474)
Kurzübersicht für CHEK1 Antikörper (AA 1-474) (ABIN187834)
Target
Alle CHEK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1-474
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Spezifität
- Recognizes chk1 kinase. Species Reactivity: Human, monkey, mouse, and rat, other species not tested. Molecular Weight: .54 kDa. Cellular Location: Cytoplasmic.
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Sterilität
- 0.2 μm filtered
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Immunogen
- GST fusion protein corresponding to amino acid sequence 1-474 of human chk1 kinase.
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anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer296) antibodyCHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer286) antibodyCHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer301) antibodyCHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer345) antibodyCHEK1 Reaktivität: Human WB, IF, ICC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibodyCHEK1 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibodyCHEK1 Reaktivität: Human WB, IHC (p), DB Wirt: Kaninchen Polyclonal RB7845-RB18425 unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibodyCHEK1 Reaktivität: Maus, Huhn ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) antibodyCHEK1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Monoclonal 2F2 unconjugated Recombinant Antibody
anti-Checkpoint Kinase 1 (CHEK1) antibodyCHEK1 Reaktivität: Human, Maus WB, ELISA Wirt: Maus Monoclonal 2G1D5 unconjugated
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Applikationshinweise
- Western blot: Use 1-10 µg/ml. The optimal dilution for a specific application should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Provided as 0.2 µm sterile filtered solution in PBS with 0.08% sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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Andere Bezeichnung
- CHK1
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Hintergrund
- One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry into mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.
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Pathways
- p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur
Target
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