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CHEK1 Antikörper (AA 1-474)

Name: CHEK1 Antikörper (AA 1-474)
SKU: ABIN187834
Price: 811.5 EUR
Availability: InStock

Dieses Schaf Polyklonal-Antikörper erkennt spezifisch CHEK1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Affe.

Produktnummer ABIN187834

Kurzübersicht für CHEK1 Antikörper (AA 1-474) (ABIN187834)

Target

Alle CHEK1 Antikörper anzeigen

CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reaktivität

Human, Maus, Ratte, Affe

Wirt

Schaf

Klonalität

Polyklonal

Konjugat

Dieser CHEK1 Antikörper ist unkonjugiert

Applikation

Western Blotting (WB)

Discover our top product CHEK1 Primärantikörper

Bindungsspezifität
36

28

19

16

9

7

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2

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2

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2

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1

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1

1

1

1

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AA 1-474

Spezifität

Recognizes chk1 kinase. Species Reactivity: Human, monkey, mouse, and rat, other species not tested. Molecular Weight: .54 kDa. Cellular Location: Cytoplasmic.

Sterilität

0.2 μm filtered

Immunogen

GST fusion protein corresponding to amino acid sequence 1-474 of human chk1 kinase.
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer301) antibody
CHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer296) antibody
CHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer286) antibody
CHEK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer345) antibody
CHEK1 Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody
CHEK1 Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Pferd, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reaktivität: Human WB, IHC (p), DB Wirt: Kaninchen Polyclonal RB7845-RB18425 unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reaktivität: Maus, Huhn ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Monoclonal 2F2 unconjugated Recombinant Antibody

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 Reaktivität: Human, Maus WB, ELISA Wirt: Maus Monoclonal 2G1D5 unconjugated

Applikationshinweise

Western blot: Use 1-10 µg/ml. The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Provided as 0.2 µm sterile filtered solution in PBS with 0.08% sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C
Target

CHEK1 (Checkpoint Kinase 1 (CHEK1))

Andere Bezeichnung

CHK1

Hintergrund

One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry into mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.

Pathways

p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur