TRAIL Antikörper

Produktnummer ABIN187524

Der Maus Monoklonal anti-TRAIL Antikörper (Klon IIIF6) (ABIN187524) detektiert spezifisch TRAIL in WB, FACS, IP, IHC (fro) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TRAIL Antikörper (ABIN187524)

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: IIIF6

Produktdetails anti-TRAIL Antikörper

Spezifität: Recognizes human TRAIL Species Reactivity: Human.

Immunogen: Recombinant human soluble TRAIL (Apo-2L)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western blotting Flow Cytometry Immunohistochemistry: Frozen sections Immunoprecipitation ELISA The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 µl of purified antibody in PBS containing 0.02% NaN3. Concentration 1 mg/ml IgG.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Andere Bezeichnung: CD253 / TRAIL

Hintergrund: Tumor necrosis factor (TNF-)-related apoptosis-inducing ligand (TRAIL, APO-2L) is thought to regulate cell death events in the immune system through TRAIL-R1 (DR4) and TRAIL-R2 (DR5), members of the TNF receptor superfamily. Like the death receptors, including Fas and TNF-R, TRAIL-R1 and TRAIL-R2 have death domains in their cytoplasmic tails that recruit proteins to initiate a cell death signaling cascade. TRAIL (APO-2L) is a 34 kDa type II transmembrane protein. TRAIL forms trimers and is a member of the TNF ligand family. Interaction between TRAIL and TRAIL-R1 and/or TRAIL-R2 rapidly induces apoptosis of TRAIL-sensitive cells. TRAIL can be injected into mice without toxic side effects. Many tumor cells are killed by TRAIL and TRAIL is currently being considered as on of the most promising potential new cancer therapeutics.

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity