SOS1 Antikörper

Produktnummer ABIN1819949

Der Maus Monoklonal anti-SOS1 Antikörper wird verwendet zum Nachweis von SOS1 in Proben von Human, Maus, Ratte, Pferd, Kaninchen, Rind (Kuh), Affe, Meerschweinchen und Schwein. Er wurde validiert für WB, ELISA und IF.

Kurzübersicht für SOS1 Antikörper (ABIN1819949)

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reaktivität: Human, Maus, Ratte, Pferd, Kaninchen, Rind (Kuh), Affe, Meerschweinchen, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Klon: SOS-1

Produktdetails anti-SOS1 Antikörper

Spezifität: Recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.

Aufreinigung: Protein A purified

Immunogen: Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Elephant, Panda, Bovine, Cat, Horse, Rabbit, Opossum, Guinea pig (100%), Dog, Turkey, Zebra finch (95%), Lizard (89%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, IF, WB (1 μg/mL)

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu SOS1

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Andere Bezeichnung: SOS1 / HGF

Hintergrund: Name/Gene ID: SOS1

Synonyms: SOS1, GINGF, NS4, SOS-1, Son of sevenless homolog 1, GF1, GGF1

Gen-ID: 6654

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling