Complement Factor H Antikörper

Produktnummer ABIN181114

Dieser Maus Monoklonal Antikörper erkennt spezifisch Complement Factor H in WB, FACS, EIA und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Complement Factor H Antikörper (ABIN181114)

Target: Complement Factor H (CFH)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Complement Factor H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 10-10-14

Produktdetails anti-Complement Factor H Antikörper

Spezifität: This antibody recognises Complement Factor H which exists in 2 forms.

Produktmerkmale: Synonyms: CFH, HF, HF1, HF2, H factor 1

Aufreinigung: Affinity Chromatography on Protein A.

Immunogen: Purified human factor H from serum.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Complement Factor H

Target: Complement Factor H (CFH)

Hintergrund: Complement factor H exists in 2 forms, the most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.Synonyms: CFH, H factor 1, HF, HF1, HF2

Gen-ID: 3075

UniProt: P08603

Pathways: Komplementsystem, Cellular Response to Molecule of Bacterial Origin