NGFR Antikörper (N-Term)
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- Target Alle NGFR Antikörper anzeigen
- NGFR (Nerve Growth Factor Receptor (NGFR))
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Bindungsspezifität
- AA 1-160, N-Term
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Reaktivität
- Human, Kaninchen, Cat, Frettchen, Affe
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser NGFR Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
- Spezifität
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This antibody recognizes CD271/NGFR, a transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within amino acids 1-160.
Cellular Localization: Cell Surface, Cytoplasmic. - Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Monkey (Cebus apella, Macaca fascicularis, mulatta, and nemestrina), Baboon (Papio anubis and Cynocephalus), Cat, Rabbit, and Ferret.
- Produktmerkmale
- Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
- Aufreinigung
- Protein-A affinity chromatography
- Immunogen
- NGFR (75kD) from A875 Melanoma Cells.
- Klon
- NGFR5
- Isotyp
- IgG1
- Top Product
- Discover our top product NGFR Primärantikörper
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- Applikationshinweise
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Flow Cytometry. Immunocytochemistry. Inhibits Binding of NGF to Melanoma Cells (see Ref.1, use antibody without azide: ABIN180340). Not suitable for Western Blotting andImmunohistochemistry. Recommended Positive Control: Melanoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS, pH ~7.4, 15 mM Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
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Store at 2-8 °C for up to one month or in aliquots at -20 °C for longer. Avoid repeated freezethaw cycles!
Shelf life: one year from despatch. - Haltbarkeit
- 12 months
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Immunohistochemistry in the diagnosis of cutaneous bacterial infections." in: The American Journal of dermatopathology, Vol. 37, Issue 3, pp. 179-93; quiz 194-6, (2015) (PubMed).
: "Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 69, Issue 6, pp. 703-13, (1994) (PubMed).
: "Expression of NGF receptor in the developing and adult primate central nervous system." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 3, pp. 860-73, (1988) (PubMed).
: "Purification and amino terminal sequencing of human melanoma nerve growth factor receptor." in: Journal of neurochemistry, Vol. 48, Issue 1, pp. 225-32, (1987) (PubMed).
: "
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Immunohistochemistry in the diagnosis of cutaneous bacterial infections." in: The American Journal of dermatopathology, Vol. 37, Issue 3, pp. 179-93; quiz 194-6, (2015) (PubMed).
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- Target
- NGFR (Nerve Growth Factor Receptor (NGFR))
- Andere Bezeichnung
- CD271 / NGFR (NGFR Produkte)
- Synonyme
- ngfr antikoerper, wu:fb38c02 antikoerper, wu:fc10h01 antikoerper, CD271 antikoerper, Gp80-LNGFR antikoerper, TNFRSF16 antikoerper, p75(NTR) antikoerper, p75NTR antikoerper, LNGFR antikoerper, RNNGFRR antikoerper, Tnfrsf16 antikoerper, p75 antikoerper, NRH1b antikoerper, fullback antikoerper, nrh1 antikoerper, p75ntr antikoerper, tnfrsf16 antikoerper, p75NGFR antikoerper, nerve growth factor receptor antikoerper, neurotrophin receptor associated death domain antikoerper, nerve growth factor receptor S homeolog antikoerper, nerve growth factor receptor (TNFR superfamily, member 16) antikoerper, NGFR antikoerper, nradd antikoerper, Ngfr antikoerper, ngfr.S antikoerper
- Hintergrund
- CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
- Molekulargewicht
- 75 kDa
- Gen-ID
- 4804
- UniProt
- P08138
- Pathways
- NF-kappaB Signalweg, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding
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