Src Antikörper (AA 10-193)

Produktnummer ABIN1724696

Der Maus Monoklonal Anti-Src-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, Src in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für Src Antikörper (AA 10-193) (ABIN1724696)

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Src Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 4F1E8

Produktdetails anti-Src Antikörper

Bindungsspezifität: AA 10-193

Verwendungszweck: SRC Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of SRC (aa10-193) expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Src Antikörper (ABIN1724696)

Li, Aurandt, Jürgensen, Jürgense, Rao, Guan: "FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5." in: Journal of cell science, Vol. 119, Issue Pt 1, pp. 47-55, (2005) (PubMed).

Summy, Trevino, Baker, Gallick: "c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK." in: Pancreas, Vol. 31, Issue 3, pp. 263-74, (2005) (PubMed).

Zheng, Yano, Matsumori, Nakataki, Muguruma, Yoshizumi, Sone et al.: "SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma ..." in: Clinical & experimental metastasis, Vol. 22, Issue 3, pp. 195-204, (2005) (PubMed).

Details zu Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Andere Bezeichnung: SRC

Hintergrund: SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian). This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Gen-ID: 6714

UniProt: P12931

Pathways: JAK-STAT Signalweg, Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling