ATM Antikörper (full length)

Produktnummer ABIN1721458

Dieser Maus Monoklonal Antikörper detektiert spezifisch ATM in WB, IHC, ELISA, IF, IP, ICC, FACS und ChIP. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte und Affe.

Kurzübersicht für ATM Antikörper (full length) (ABIN1721458)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Chromatin Immunoprecipitation (ChIP)

Klon: 2C1

Produktdetails anti-ATM Antikörper

Bindungsspezifität: AA 2577-3056, full length

Spezifität: Reacts with human ATM. Cross-reacts with mouse, rat and monkey protein.

Aufreinigung: Purified

Immunogen: GST fusion protein expressed in E. coli corresponding to aa 2577- 3056 of full-length ATM.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB1:500 - 1:3000 IHC-P5 μg/mL IP1 - 10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.4

Handhabung: Dilute in PBS or medium that is identical to that used in the assay system.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Stable for at least one year at -20°C or -70°C. Avoid multiple freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Andere Bezeichnung: ATM

Hintergrund: ATM is a 370 kD nuclear phosphoprotein,which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.

Serine-protein kinase ATM Ataxia telangiectasia mutated, A-T mutated gene name: ATM AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1

Gen-ID: 472

UniProt: Q13315

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus