ZAP70 Antikörper (zeta-Chain (TCR) Associated Protein Kinase 70kDa) (pTyr292) (Cy5)

Details for Product anti-ZAP70 Antibody No. ABIN1705036
Antigen
  • SRK
  • STCD
  • STD
  • TZK
  • ZAP-70
  • 70kDa
  • AI327364
  • Srk
  • mrtle
  • mur
  • zap70
  • MGC80670
  • MGC88962
  • ZAP70
  • zgc:110383
  • zeta chain of T-cell receptor associated protein kinase 70
  • putative tyrosine-protein kinase zap-70
  • zeta-chain (TCR) associated protein kinase
  • zeta chain of T cell receptor associated protein kinase 70
  • zeta-chain (TCR) associated protein kinase 70kDa
  • zeta chain of T cell receptor associated protein kinase 70kDa L homeolog
  • zeta chain of T cell receptor associated protein kinase 70kDa
  • tyrosine-protein kinase ZAP-70
  • ZAP70
  • Smp_149470
  • Zap70
  • zap70.L
  • zap70
  • LOC707555
  • LOC100342021
  • LOC100390922
  • LOC100542877
Epitop
pTyr292
60
57
54
30
29
26
22
13
12
11
10
10
9
7
7
7
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
601
251
180
14
11
9
8
7
6
6
4
3
1
Wirt
Kaninchen
371
210
17
3
2
Klonalität
Polyklonal
Konjugat
Dieser ZAP70 Antikörper ist konjugiert mit Cy5
26
26
18
17
14
12
10
10
10
10
10
9
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
321
192
185
164
118
87
65
51
42
13
7
7
3
2
2
2
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human Zap-70 around the phosphorylation site of Tyr292
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere ZAP70 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Zap70 (ZAP70 Antibody Abstract)
Hintergrund

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Synonyms: ZAP70 phospho Y292, ZAP70 phospho Tyr292, p-Zap-70Tyr292, p-Zap-70Y292, p-ZAP70 Y292, p-ZAP70 Tyr292, ZAP-70, ZAP 70, ZAP70, zeta-associated protein 70, ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, Syk-related tyrosine kinase. SRK, STD, TZK, ZAP70_HUMAN, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein.

Gen-ID 7535
Pathways T-Zell Rezeptor Signalweg
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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