ANAPC10 Antikörper (Anaphase Promoting Complex Subunit 10) (Cy5)

Details for Product anti-ANAPC10 Antibody No. ABIN1704410
Antigen
  • APC10
  • DOC1
  • 1500026N15Rik
  • A830003M23Rik
  • CG11419
  • Dmel\\CG11419
  • ANAPC10
  • SPBC1E8.06
  • anapc10
  • MGC85037
  • DDBDRAFT_0202332
  • DDBDRAFT_0235160
  • DDB_0202332
  • DDB_0235160
  • anaphase promoting complex subunit 10
  • Anaphase Promoting Complex subunit 10
  • anaphase promoting complex subunit DOC1
  • anaphase-promoting complex subunit Apc10
  • anaphase promoting complex subunit
  • predicted protein
  • anaphase promoting complex subunit 10 S homeolog
  • ANAPC10
  • Anapc10
  • APC10
  • DOC1
  • apc10
  • CAALFM_C107850CA
  • anapc10
  • LOC692856
  • anapc10.S
  • NAEGRDRAFT_66759
Reaktivität
Human, Maus, Ratte (Rattus)
76
35
28
2
2
2
2
2
1
1
1
1
1
1
Wirt
Kaninchen
66
11
Klonalität
Polyklonal
Konjugat
Dieser ANAPC10 Antikörper ist konjugiert mit Cy5
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
53
28
28
12
12
8
5
4
4
3
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human APC10
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere ANAPC10 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Apc10 (ANAPC10 Antibody Abstract)
Hintergrund

Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.

Synonyms: ANAPC 10, anapc10, Anaphase promoting complex 10, Anaphase promoting complex subunit 10, Anaphase-promoting complex subunit 10, Apc 10, APC10, APC10_HUMAN, Cyclosome subunit 10, DKFZP564L0562, Doc 1, Doc1, OTTHUMP00000220297, OTTHUMP00000220298, OTTHUMP00000220299, OTTHUMP00000220300, OTTHUMP00000220303.

Gen-ID 10393
Pathways M Phase
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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