WISP3 Antikörper (AA 221-320) (Biotin)

Produktnummer ABIN1700981

Produktdetails anti-WISP3 Antikörper (Biotin)

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Bindungsspezifität: AA 221-320

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WISP3 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Sheep,Horse,Rabbit,Monkey

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WISP3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu WISP3

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Andere Bezeichnung: WISP3 (WISP3 Produkte)

Synonyme: CCN6 antikoerper, LIBC antikoerper, PPAC antikoerper, PPD antikoerper, ENSMUSG00000062074 antikoerper, Gm735 antikoerper, WISP-3 antikoerper, RGD1564120 antikoerper, WISP3 antikoerper, si:dkey-119m7.6 antikoerper, WNT1 inducible signaling pathway protein 3 antikoerper, WISP3 antikoerper, Wisp3 antikoerper, wisp3 antikoerper

Hintergrund:

Synonyms: CCN 6, CCN family member 6, CCN6, CYR61, LIBC, Lost in inflammatory breast cancer tumor suppressor protein, MGC125987, MGC125988, MGC125989, OTTHUMP00000040421, PPAC, PPD, UNQ462/PRO790/PRO956, WISP 3, WISP-3, WISP3, WISP3_HUMAN, WNT 1 inducible signaling pathway protein 3, Wnt 1 signaling pathway protein 3, WNT1 inducible signaling pathway protein 3, WNT1 inducible signaling pathway protein 3 precursor, WNT1-inducible-signaling pathway protein 3.

Background: Wnt-induced secreted protein (WISP)-1, WISP-2 and WISP-3 are members of the CCN family of growth factors, which include connective tissue growth factor (CTGF) and Cyr61. WISP-1, WISP-2 and WISP-3 share significant sequence similarity, including four conserved cysteine-rich domains, and they are believed to function as dimers in their active forms. WISP-1 expression is observed in various tissues including adult heart, kidney and spleen, while WISP-2 expression predominates in skeletal muscle, colon and ovary. Both WISP-1 and WISP-2 are upregulated in cells transformed with the proto-oncogene Wnt-1, and they are also more highly expressed in human colon tumors, suggesting that these proteins may participate in tumor development. WISP-3 is involved in normal post-natal skeletal growth, and it is also implicated in the development of the autosomal recessive skeletal disorder progressive pseudorheumatoid dysplasia, which affects cartilage homeostasis by disrupting the growth of chondrocyte and normal cell columnar organization.

Gen-ID: 8838

Pathways: WNT Signalweg, Growth Factor Binding