FGFR1 Antikörper (pTyr154) (AbBy Fluor® 488)

Produktnummer ABIN1695981

Dieses Anti-FGFR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FGFR1 in IF (p) und IF (cc). Geeignet für Human.

Kurzübersicht für FGFR1 Antikörper (pTyr154) (AbBy Fluor® 488) (ABIN1695981)

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR1 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-FGFR1 Antikörper (AbBy Fluor® 488)

Bindungsspezifität: pTyr154

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr154

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Andere Bezeichnung: FGFR1

Hintergrund:

Synonyms: FGFR1 phospho Y154, FGFR1 phospho Tyr154, p-FGFR1 phospho Y154, bFGF R, BFGFR, C FGR, CD 331, CD331, CD331 antigen, CEK, FGFBR, FGFR 1, Fibroblast growth factor receptor 1, FLG, FLG protein, FLJ14326, FLT 2, FLT2, Fms like tyrosine kinase 2, Fms related tyrosine kinase 2, Fms related tyrosine kinase 2 Pfefer syndrome, H2, H3, H4, H5, HBGFR, Heparin binding growth factor receptor, Hydroxyaryl protein kinase, KAL 2, KAL2, MFR, N SAM, N sam tyrosine kinase, Protein tyrosine kinase, Tyrosylprotein kinase, Basic fibroblast growth factor receptor 1, FGFR1_HUMAN.

Background: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

Gen-ID: 2260

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteine