BAX Antikörper (AA 28-56)

Produktnummer ABIN1539948

Dieses Anti-BAX-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von BAX in WB. Geeignet für Human.

Kurzübersicht für BAX Antikörper (AA 28-56) (ABIN1539948)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 557CT5-2-1

Produktdetails anti-BAX Antikörper

Bindungsspezifität: AA 28-56

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This BAX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from human BAX .

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB: 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: BAX Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: BAX

Hintergrund: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Molekulargewicht: 21184

Gen-ID: 581

NCBI Accession: NP_004315, NP_620116, NP_620118, NP_620119

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response