Caspase 6 Antikörper (Cleaved-Asp179)

Produktnummer ABIN1536082

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-Caspase 6 Antikörper wird verwendet zum Nachweis von Caspase 6 in Proben von Human und Ratte. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für Caspase 6 Antikörper (Cleaved-Asp179) (ABIN1536082)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Caspase 6 Antikörper

Bindungsspezifität: AA 130-179, Cleaved-Asp179

Verwendungszweck: Cleaved-Caspase-6 p18 (D179) Antibody

Spezifität: Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-6 p18 protein resulting from cleavage adjacent to D179.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 6. AA range:130-179

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Referenzen für anti-Caspase 6 Antikörper (ABIN1536082)

Yashiro, Qiu, Hasegawa, Zhang, Matsuzaki, Hirakawa: "An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells." in: British journal of cancer, (2011) (PubMed).

Details zu Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Andere Bezeichnung: Caspase 6

Hintergrund:

Synonyms: CASP6, MCH2, Caspase-6, CASP-6, Apoptotic protease Mch-2

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015],

Gene Name: CASP6

Protein Name: Caspase6

Molekulargewicht: 20 and 35 kDa

Gen-ID: 839

OMIM: 601532

UniProt: P55212

Pathways: Apoptose, Caspase Kaskade in der Apoptose