BRCA2 Antikörper (AA 31-80)

Produktnummer ABIN1533759

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BRCA2 in ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für BRCA2 Antikörper (AA 31-80) (ABIN1533759)

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-BRCA2 Antikörper

Bindungsspezifität: AA 31-80

Verwendungszweck: BRCA2 Antibody

Spezifität: BRCA2 Polyclonal Antibody detects endogenous levels of BRCA2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human BRCA2. AA range:31-80

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2

Hintergrund:

Synonyms: BRCA2, FACD, FANCD1, Breast cancer type 2 susceptibility protein, Fanconi anemia group D1 protein

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],

Gene Name: BRCA2

Protein Name: Breast cancer type 2 susceptibility protein

Molekulargewicht: 384 kDa

Gen-ID: 675

OMIM: 114480

UniProt: P51587

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location