Cytokeratin 18 Antikörper (AA 381-430)
Kurzübersicht für Cytokeratin 18 Antikörper (AA 381-430) (ABIN1533323)
Target
Alle Cytokeratin 18 (KRT18) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 381-430
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Verwendungszweck
- Cytokeratin 18 Antibody
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Spezifität
- Cytokeratin 18 Polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Reinheit
- > 95 %
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Immunogen
- The antiserum was produced against synthesized peptide derived from human Keratin 18. AA range:381-430
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Isotyp
- IgG
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Applikationshinweise
- Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C/1 year
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Haltbarkeit
- 12 months
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- Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))
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Andere Bezeichnung
- Keratin 18
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Hintergrund
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Synonyms: KRT18, CYK18, PIG46, Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18
Background: tumor protein p53(TP53) Homo sapiens This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013],
Gene Name: KRT18
Protein Name: Keratin type I cytoskeletal 18
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Molekulargewicht
- 48 kDa
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OMIM
- 148070
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UniProt
- P05783
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose
Target
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