BRCA1 Antikörper (AA 1491-1540)

Produktnummer ABIN1532821

Der Kaninchen Polyklonal anti-BRCA1 Antikörper wird verwendet zum Nachweis von BRCA1 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA, IHC (p) und IF (p).

Kurzübersicht für BRCA1 Antikörper (AA 1491-1540) (ABIN1532821)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-BRCA1 Antikörper

Bindungsspezifität: AA 1491-1540

Verwendungszweck: BRCA1 Antibody

Spezifität: BRCA1 Polyclonal Antibody detects endogenous levels of BRCA1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human BRCA1. AA range:1491-1540

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Andere Bezeichnung: BRCA1

Hintergrund:

Synonyms: BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53

Background: transforming growth factor beta receptor 3(TGFBR3) Homo sapiens This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010],

Gene Name: BRCA1

Protein Name: Breast cancer type 1 susceptibility protein

Molekulargewicht: 207 kDa

OMIM: 113705

UniProt: P38398

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus