CSNK1A1 Antikörper (pTyr294)

Produktnummer ABIN1532040

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CSNK1A1 in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für CSNK1A1 Antikörper (pTyr294) (ABIN1532040)

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSNK1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-CSNK1A1 Antikörper

Bindungsspezifität: AA 260-309, pTyr294

Verwendungszweck: Casein Kinase Iα (phospho Tyr294) Antibody

Spezifität: Phospho-Casein Kinase Iα (Y294) Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Y294.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CK-1 alpha around the phosphorylation site of Tyr294. AA range:260-309

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CSNK1A1

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Andere Bezeichnung: CK-1 alpha

Hintergrund:

Synonyms: CSNK1A1, Casein kinase I isoform alpha, CKI-alpha, CK1, CSNK1A1L, Casein kinase I isoform alpha-like, CKI-alpha-like, CK1

Background: CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2. asein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed: 11955436, PubMed: 1409656, PubMed: 18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed: 23902688). asein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Gene Name: CSNK1A1

Protein Name: Casein kinase I isoform alpha

Molekulargewicht: 38 kDa

Gen-ID: 1452, 122011

OMIM: 600505

UniProt: P48729

Pathways: WNT Signalweg, Hedgehog Signalweg