TDG Antikörper

Produktnummer ABIN1526109

Dieses Anti-TDG-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TDG in WB und EIA. Geeignet für Human.

Kurzübersicht für TDG Antikörper (ABIN1526109)

Target: TDG (Thymine-DNA Glycosylase (TDG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TDG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: AT2F7

Produktdetails anti-TDG Antikörper

Aufreinigung: Protein-A affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) containing 10 % Glycerol, 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu TDG

Target: TDG (Thymine-DNA Glycosylase (TDG))

Andere Bezeichnung: TDG

Hintergrund: G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.Synonyms: G/T mismatch-specific thymine DNA glycosylase

Pathways: DNA Reparatur, Chromatin Binding