MYD88 Antikörper (AA 171-220)

Produktnummer ABIN1453590

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-MYD88 Antikörper (ABIN1453590) detektiert spezifisch MYD88 in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte und Schwein.

Kurzübersicht für MYD88 Antikörper (AA 171-220) (ABIN1453590)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYD88 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-MYD88 Antikörper

Bindungsspezifität: AA 171-220

Verwendungszweck: MyD88 Antibody

Spezifität: MyD88 Polyclonal Antibody detects endogenous levels of MyD88 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human MyD88. AA range:171-220

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunocytochemistry: 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Referenzen für anti-MYD88 Antikörper (ABIN1453590)

Valerio, Minderman, Mace, Awad: "β-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages." in: Cellular immunology, Vol. 285, Issue 1-2, pp. 76-83, (2014) (PubMed).

Details zu MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Andere Bezeichnung: MyD88

Hintergrund:

Synonyms: MYD88, Myeloid differentiation primary response protein MyD88

Background: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

Gene Name: MyD88

Protein Name: Myeloid differentiation primary response protein MyD88

Molekulargewicht: 33 kDa

Gen-ID: 4615

OMIM: 602170

UniProt: Q99836

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades