ATR Antikörper

Produktnummer ABIN1449281

Der Maus-Monoklonal Anti-ATR-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von ATR in Proben aus Human. }

Kurzübersicht für ATR Antikörper (ABIN1449281)

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 4D7

Produktdetails anti-ATR Antikörper

Sequenz: CPCELEHSIK PLFQHSPGDS SQED

Spezifität: This antibody reacts with human ATR.

Aufreinigung: Protein A agarose

Immunogen: Carrier protein (CP) conjugated synthetic peptide

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu ATR

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Andere Bezeichnung: ATR / FRP1

Hintergrund: ATR (ataxia telangiectasia and Rad-3-related) is one of the most important checkpoint proteins in mammalian cells responding to DNA damage. ATR is a member of the phosphatidylinositol kinase-related protein family that includes ATM (ataxia telangiectasia mutated). These kinases are essential for signaling the presence of DNA damage or replication blocks and activating cell cycle checkpoints. It is reported that checkpoint kinase 1 (CHK1), RAD9, RAD17, Histone H2AX, p53, and BRCA1 are phosphorylated in response to genotoxic stress in an ATR-dependent manner. ATR also phosphorylates ATR-interacting protein (ATRIP) that regulates ATR expression, and is an essential component of the DNA damage checkpoint signaling pathways. In addition, homozygous deletion of ATR in mice causes early embryonic lethality, suggesting that ATR has essential functions during development.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR

Gen-ID: 545

NCBI Accession: NP_001175

UniProt: Q13535

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus