TET2 Antikörper (AA 1165-1215) (Cy7)

Produktnummer ABIN1420646

Der Kaninchen Polyklonal Anti-TET2-Antikörper wurde für IF (p) validiert. Er ist geeignet, TET2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für TET2 Antikörper (AA 1165-1215) (Cy7) (ABIN1420646)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TET2 Antikörper ist konjugiert mit Cy7

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-TET2 Antikörper (Cy7)

Bindungsspezifität: AA 1165-1215

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TET2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Kommentare:

Exitation/Emission: 743nm/767nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4 °C for 12 months.

Haltbarkeit: 12 months

Details zu TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Andere Bezeichnung: TET2

Hintergrund: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Synonyms: MDS, KIAA1546, Methylcytosine dioxygenase TET2, TET2, Nbla00191

Gen-ID: 54790

UniProt: Q6N021

Pathways: Warburg Effekt