SKP1 Antikörper (AA 81-163) (Biotin)

Produktnummer ABIN1398805

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SKP1 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für SKP1 Antikörper (AA 81-163) (Biotin) (ABIN1398805)

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKP1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SKP1 Antikörper (Biotin)

Bindungsspezifität: AA 81-163

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SKP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SKP1

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Andere Bezeichnung: SKP1

Hintergrund:

Synonyms: Cyclin A/CDK2 associated p19, Cyclin A/CDK2 associated protein p19, Cyclin-A/CDK2-associated protein p19, EMC 19, EMC19, OCP 2, OCP II, OCP II protein, OCP-2, OCP-II, OCP2, OCPII, organ of Corti protein 2, Organ of Corti protein II, p19A, p19skp1, RNA polymerase II elongation factor like protein, RNA polymerase II elongation factor like protein OCP2, RNA polymerase II elongation factor-like protein, S phase kinase associated protein 1, S phase kinase associated protein 1A, S phase kinase associated protein 1A p19A, S-phase kinase-associated protein 1, SIII, Skp 1, SKP 1A, skp1, SKP1_HUMAN, SKP1A, TCEB1L, Transcription elongation factor B SIII polypeptide 1 like, Transcription Elongation Factor B 1 like, Transcription Elongation Factor B 1-like, Transcription elongation factor B, Transcription elongation factor B SIII polypeptide 1 like.

Background: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22', the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.

Gen-ID: 6500

Pathways: Zellzyklus, Hedgehog Signalweg, Mitotic G1-G1/S Phases