c-MET Antikörper

Produktnummer ABIN1381745

Der Ratte Monoklonal Anti-c-MET-Antikörper wurde für FACS und cELISA validiert. Er ist geeignet, c-MET in Proben von Human zu detektieren.

Kurzübersicht für c-MET Antikörper (ABIN1381745)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser c-MET Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Klon: BCI-3E7

Produktdetails anti-c-MET Antikörper

Spezifität: Anti-human c-Met

Produktmerkmale: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding human c-Met

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Details zu c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung: c-Met

Hintergrund: C-MET is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. c-MET is produced as a single-chain precursor and plays en essential role in embryonic development and wound healing. It belongs to the class of Single-pass type I membrane proteins and it is normally expressed by cells of epithelial origin while the expression of HGF is restricted to cells of mesenchymal origin in an almost perfect paracrine paradigm. Overexpression of c-MET can be found in several kinds of tumor progression.

UniProt: P08581

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor