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PKM2 Antikörper (pSer37)

Name: PKM2 Antikörper (pSer37)
SKU: ABIN1355883
Price: 340.56 EUR
Availability: InStock

Dieses Anti-PKM2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PKM2 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

(1 reference)

Produktnummer ABIN1355883

Kurzübersicht für PKM2 Antikörper (pSer37) (ABIN1355883)

Target

Alle PKM2 Antikörper anzeigen

PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität

Human

Wirt

Kaninchen

Klonalität

Polyklonal

Konjugat

Dieser PKM2 Antikörper ist unkonjugiert

Applikation

Western Blotting (WB)

Discover our top product PKM2 Primärantikörper

Bindungsspezifität
21

16

8

8

7

7

6

4

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer37

Spezifität

The antibody detects endogenous level of PKM2 only

Immunogen

Peptide sequence around phosphorylation site of pSer37 (I-D-S (p) -P-P) derived from Human PKM2.
anti-Pyruvate Kinase M2 (PKM2) (AA 141-248) antibody
PKM2 Reaktivität: Human WB, IHC, FACS, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 294-470) antibody
PKM2 Reaktivität: Human WB, IHC, FACS, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 476-505), (C-Term) antibody
PKM2 Reaktivität: Human, Maus, Ratte, Affe WB, IHC (p), IF Wirt: Kaninchen Polyclonal RB3697 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (pTyr105) antibody
PKM2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 383-417), (C-Term) antibody
PKM2 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB18405 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 116-145) antibody
PKM2 Reaktivität: Human WB, IHC, FACS, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 476-505) antibody
PKM2 Reaktivität: Human, Maus, Ratte, Primate WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 255-350) antibody
PKM2 Reaktivität: Human, Maus, Ratte WB, FACS, ELISA, IHC (p), ICC, IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 116-145), (N-Term) antibody
PKM2 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB15338 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 121-151), (N-Term) antibody
PKM2 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB5870 unconjugated

Applikationshinweise

Western Blot: 1:500-1000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Lagerung

4 °C/-20 °C
Yang, Zheng, Xia, Ji, Chen, Guo, Lyssiotis, Aldape, Cantley, Lu: "ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." in: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).
Target

PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung

PKM2

Hintergrund

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Molekulargewicht

60 kDa

Pathways

Warburg Effekt