Serotonin Receptor 2B Antikörper (N-Term)

Produktnummer ABIN121986

Dieser Anti-Serotonin Receptor 2B Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Serotonin Receptor 2B in IHC (p). Geeignet für Human.

Kurzübersicht für Serotonin Receptor 2B Antikörper (N-Term) (ABIN121986)

Target: Serotonin Receptor 2B (HTR2B)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 2B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Serotonin Receptor 2B Antikörper

Bindungsspezifität: N-Term

Spezifität: Reacts with 5-HT2B receptor (Family GPCR, Subfamily: Serotonin).

Aufreinigung: Peptide immunogen affinity chromatography

Immunogen: Synthetic peptide - KLH conjugated.

Anwendungsinformationen

Applikationshinweise: Immunohistochemsiry on paraffin embedded sections (3 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C for up to one month or at -20 °C for longer. Avoid repeatedfreezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Serotonin Receptor 2B

Target: Serotonin Receptor 2B (HTR2B)

Hintergrund: 5-HT2B, a Serotonin Receptor, activates phospholipase C upon binding serotonin, which results in a rise in intracellular calcium. It is known that 5-HT2B regulates cardiovascular function during development and in adulthood, mice lacking functional 5-HT2B receptors died of heart defects during gestation or neonatally, and adult mutant mice displayed cardiopathy, including myocyte disarray and ventricular dilation. Abnormal vascular proliferation causes an increase in pulmonary blood pressure, which is associated with an increase in 5-HT2B receptor, resulting in the development of pulmonary hypertension. It has also been reported that the 5-HT2B is involved in cell-cycle regulation via interaction with tyrosine kinase pathways. 5-HT2B receptors may have a role in the initiation of migraine headaches, and selective antagonists may prove therapeutic in migraine treatment. 5-HT2B receptor is expressed in many tissues including human liver, kidney, lung, heart, pancreas, spleen, brain, spinal cord, gastrointestinal tract, placenta, and coronary and pulmonary arteries. It has also been reported in embryonic mouse heart and spinal cord. ESTs have been isolated from heart/melanocyte/uterus, kidney, prostate, skin, and thyroid libraries.Synonyms: 5-HT-2B, 5-HT2B, 5-hydroxytryptamine receptor 2B

Gen-ID: 3357

UniProt: P41595

Pathways: JAK-STAT Signalweg, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process