TRAIL Antikörper

Produktnummer ABIN1169389

Dieser Maus Monoklonal Antikörper detektiert spezifisch TRAIL in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für TRAIL Antikörper (ABIN1169389)

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: HS501

Produktdetails anti-TRAIL Antikörper

Verwendungszweck: anti-TRAIL (human), mAb (HS501)

Spezifität: Recognizes human TRAIL.

Produktmerkmale: Monoclonal Antibody. Recognizes human TRAIL. Isotype: Mouse IgG1. Clone: HS501. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. TNF-related apoptosis-inducing ligand (TRAIL, Apo2L,CD253, TNFSF10) is a type II transmembrane protein of about 34 kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4, Apo2, CD261, TNFRSF10A), TRAIL-R2 (DR5, KILLER, TRICK2A, TRICK2B, CD262, TNFRSF10B), TRAIL-R3 (DcR1, LIT, TRID, CD263, TNFRSF10C), TRAIL-R4 (DcR2, TRUNDD, CD264, TNFRSF10D), and osteoprotegerin (OPG, OCIF, TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). .

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human TRAIL.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-TRAIL Antikörper (ABIN1169389)

Luetzkendorf, Mueller, Mueller, Caysa, Nerger, Schmoll: "Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence." in: Journal of cellular and molecular medicine, Vol. 14, Issue 9, pp. 2292-304, (2010) (PubMed).

Wenger, Mattern, Penzel, Gassler, Haas, Sprick, Walczak, Krammer, Debatin, Herr: "Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors." in: Cell death and differentiation, Vol. 13, Issue 10, pp. 1740-51, (2006) (PubMed).

Huber, Fais, Iero, Lugini, Canese, Squarcina, Zaccheddu, Colone, Arancia, Gentile, Seregni, Valenti, Ballabio, Belli, Leo, Parmiani, Rivoltini: "Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape." in: Gastroenterology, Vol. 128, Issue 7, pp. 1796-804, (2005) (PubMed).

Washburn, Weigand, Grosse-Wilde, Janke, Stahl, Rieser, Sprick, Schirrmacher, Walczak: "TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 4, pp. 1814-21, (2003) (PubMed).

Details zu TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Andere Bezeichnung: TRAIL

Hintergrund:

Alternate Names/Synonyms: Apo-2L, TNFSF10, CD253

Product Description: TNF-related apoptosis-inducing ligand (TRAIL, Apo2L,CD253, TNFSF10) is a type II transmembrane protein of about 34 kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4, Apo2, CD261, TNFRSF10A), TRAIL-R2 (DR5, KILLER, TRICK2A, TRICK2B, CD262, TNFRSF10B), TRAIL-R3 (DcR1, LIT, TRID, CD263, TNFRSF10C), TRAIL-R4 (DcR2, TRUNDD, CD264, TNFRSF10D), and osteoprotegerin (OPG, OCIF, TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). .

UniProt: P50591

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity