GDNF Antikörper (Biotin)

Produktnummer ABIN116019

Dieses Anti-GDNF-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GDNF in WB, IHC (fro) und EIA. Geeignet für Human.

Kurzübersicht für GDNF Antikörper (Biotin) (ABIN116019)

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GDNF Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Produktdetails anti-GDNF Antikörper (Biotin)

Spezifität: Human Glial Derived Neurotrophic Factor.

Aufreinigung: Affinity chromatography.

Immunogen: Highly pure (>98%) recombinant hGDNF.

Anwendungsinformationen

Applikationshinweise: ELISA: To detect hGDNF by direct ELISA (using 100 ml/well antibody solution) this GDNFantibody can be used at a concentration of 0.15-0.30 μg/mL. Used in conjunction withcompatible secondary reagents, allows the detection of at least 0.2 ng/well of recombinanthGDNF. Western Blot: To detect hGDNF by Western Blot analysis this GDNF antibody can be used ata concentration of 0.1-0.2 mg/mL. Used in conjunction with compatible secondary reagentsthe detection limit for recombinant hGDNF is 1.5-3.0 ng/lane, under either reducing ornon-reducing conditions.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile PBS containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.2 without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Centrifuge vial prior to opening! This product is photosensitive and should be protected from light

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C. DO NOT FREEZE!

Details zu GDNF

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Andere Bezeichnung: GDNF

Hintergrund: Glial cell line derived neurotrophic factor (GDNF) is a highly conserved neurotrophic factor that is a distant member of the TGF beta superfamily. The GDNF gene product is processed to a disulphide-linked homodimer, which is a ligand for the RET protooncogene. GDNF protects and repairs dopamine-containing neurons, which degenerate in Parkinson's disease, and motor neurons, which die in amyotrophic lateral sclerosis. The use of GDNF in the treatment of Parkinson's disease has shown promise in the clinic. Treatment of spinal cord injuries with GDNF has also produced neurological improvement.Synonyms: ATF, Astrocyte-derived trophic factor, Glial cell line-derived neurotrophic factor

Gen-ID: 2668

NCBI Accession: NP_000505

UniProt: P39905

Pathways: RTK Signalweg, Synaptic Membrane, Tube Formation, Autophagie, Smooth Muscle Cell Migration