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TRAIL Antikörper

TNFSF10 Reaktivität: Human WB, Func, EIA Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN115786
  • Target Alle TRAIL (TNFSF10) Antikörper anzeigen
    TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
    Reaktivität
    • 105
    • 36
    • 31
    • 4
    • 2
    Human
    Wirt
    • 79
    • 43
    • 5
    Maus
    Klonalität
    • 82
    • 45
    Monoklonal
    Konjugat
    • 70
    • 16
    • 10
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRAIL Antikörper ist unkonjugiert
    Applikation
    • 91
    • 35
    • 28
    • 24
    • 13
    • 13
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)
    Spezifität
    Recognises Human TRAIL/APO-II.
    Aufreinigung
    Affinity Chromatography on Protein A
    Immunogen
    Recombinant Human TRAIL/APO-II
    Isotyp
    IgG1
    Top Product
    Discover our top product TNFSF10 Primärantikörper
  • Applikationshinweise
    ELISA: In a Sandwich ELISA (assuming 100 μL/well), a concentration of 1-2 μg/mL of thisantibody will detect at least 0.2 ng/well of recombinant Human TRAIL/APO-II when usedwith Biotin conjugated anti-Human TRAIL/APO-II (cat. PP1084B) as the detection antibody. Western Blot: To detect Human TRAIL/Apo2L by Western Blot analysis this antibody can beused at a concentration of 0.25-0.50 μg/mL. Used in conjunction with compatiblesecondary reagents the detection limit for recombinant Human TRAIL/Apo2L is 0.25-1.0 ng/lane, under reducing or non-reducing conditions. Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity ofHuman TRAIL/Apo2L (10.0 ng/mL), a concentration of 0.30-0.60 μg/mL of this antibody isrequired.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore in sterile water to a concentration of 1.0 mg/mL.
    Konzentration
    1.0 mg/mL
    Buffer
    PBS without preservatives.
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • Target
    TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
    Andere Bezeichnung
    CD253 / TRAIL (TNFSF10 Produkte)
    Synonyme
    APO2L antikoerper, Apo-2L antikoerper, CD253 antikoerper, TL2 antikoerper, TRAIL antikoerper, A330042I21Rik antikoerper, AI448571 antikoerper, APO-2L antikoerper, Ly81 antikoerper, Trail antikoerper, tl2 antikoerper, apo2l antikoerper, cd253 antikoerper, trail antikoerper, apo-2l antikoerper, trail1 antikoerper, xtrail1 antikoerper, tnfsf10l2 antikoerper, zgc:92320 antikoerper, TNLG6A antikoerper, TNF superfamily member 10 antikoerper, tumor necrosis factor (ligand) superfamily, member 10 antikoerper, tumor necrosis factor superfamily member 10 antikoerper, TNF superfamily member 10 S homeolog antikoerper, TNFSF10 antikoerper, Tnfsf10 antikoerper, tnfsf10.S antikoerper, tnfsf10 antikoerper
    Hintergrund
    Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues.Synonyms: APO2L, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, TNFSF10, Tumor necrosis factor ligand superfamily member 10
    Gen-ID
    8743
    NCBI Accession
    NP_003801
    UniProt
    P50591
    Pathways
    Apoptose, Positive Regulation of Endopeptidase Activity
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