GZMB Antikörper (N-Term)

Produktnummer ABIN115413

Der Kaninchen Polyklonal anti-GZMB Antikörper (ABIN115413) detektiert spezifisch GZMB in IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für GZMB Antikörper (N-Term) (ABIN115413)

Target: GZMB (Granzyme B (GZMB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GZMB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GZMB Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts with a 32 kDa protein.
Cellular Localization: Cytoplasmic

Aufreinigung: Purified

Immunogen: A synthetic peptide from the N-terminus of human Granzyme B.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Embedded Tissues: Use 1/50-1100 dilution in an ABC method (30 minutes at room temperature)Recommended Positive Control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Citrate Buffer, pH 6.0 containing Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Hintergrund: Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzymes B is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTLs or NK cells.Synonyms: CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Cathepsin G-like 1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, GRB, Granzyme-2, Lymphocyte protease, SECT, T-cell serine protease 1-3E

Gen-ID: 3002

NCBI Accession: NP_004122

UniProt: P10144

Pathways: Apoptose, Caspase Kaskade in der Apoptose