SHP1 Antikörper

Produktnummer ABIN114551

Der Maus Monoklonal anti-SHP1 Antikörper wird verwendet zum Nachweis von SHP1 in Proben von Human. Er wurde validiert für WB, IF, IHC (fro) und EIA.

Kurzübersicht für SHP1 Antikörper (ABIN114551)

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SHP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: PTY10

Produktdetails anti-SHP1 Antikörper

Spezifität: This antibody recognizes single 67 kDa PTP1-C in Human cells that express the enzyme and the SH2(C) domain.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein G.

Immunogen: Purified recombinant protein corresponding to full-length PTP1-C.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with double distillated water to adjust the final concentration to 1.0 mg/mL

Buffer: 0.01 M PBS, pH 7.2 without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Andere Bezeichnung: PTPN6

Hintergrund: The phosphorylation state of receptors and signal transduction molecules influences almost every cell activities. The phosphorylation rate is regulated by kinases which add phosphate group and by phosphatases which remove phosphate group form the amino acid residues on protein molecules. Protein tyrosine phosphatase 1 C (PTP1C) is a tyrosine phosphatase highly expressed in heomatopoietic cells. PTP1C was found to co-precipitate with B lymphocytespecific cell surface glycoprotein CD22, after anti-immunoglobulin stimulation. Study with PTP1C deficient mice showed that the phosphatase may implicate with negative selection in B cell immunity.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6

Gen-ID: 5777

NCBI Accession: NP_002822

UniProt: P29350

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling