KLKB1 Antikörper

Produktnummer ABIN111208

Dieser Maus Monoklonal Antikörper detektiert spezifisch KLKB1 in WB, EIA und Func. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für KLKB1 Antikörper (ABIN111208)

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KLKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)

Klon: 901

Produktdetails anti-KLKB1 Antikörper

Spezifität: Recognizes two variants of Prekallikrein and its activation products Kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and Antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). Recognizes Prekallikrein and its activation products in Human, Chimpanzee, Rhesus, and Baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in Human and Rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue Kallikrein

Aufreinigung: Protein G chromatography.

Immunogen: Purified Human prekallikrein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Suitable for use in ELISA and Western blot. Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasmasamples.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.6 mg/mL (OD280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KLKB1

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Hintergrund: Plasma Kallikrein 1B is a serine proteinase of the S1 family It is secreted by the liver, kidney, adrenal gland and placenta. The zymogen is referred to as prekallikrein (PK) and is activated by Factor XIIa to an active two chain form, plasma kallikrein. In Fletcher syndrome plasma kallikrein is deficient, resulting in a prolonged partial thromboplastin time (PT).Synonyms: Fletcher factor, Plasma kallikrein

Gen-ID: 3818

NCBI Accession: NP_000883

UniProt: P03952

Pathways: Komplementsystem, Brown Fat Cell Differentiation