XPC Antikörper (C-Term)

Produktnummer ABIN1109520

Dieses Anti-XPC-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von XPC in WB, EIA und IHC (fro). Geeignet für Human.

Kurzübersicht für XPC Antikörper (C-Term) (ABIN1109520)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-XPC Antikörper

Bindungsspezifität: C-Term

Spezifität: Reacts with Human 105 kDa XPC protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from C-terminal domain of Human XPC protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Details zu XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Andere Bezeichnung: XPC / XPCC

Hintergrund: Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair. XPC may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XPC), also known as xeroderma pigmentosum III (XP3). XPC is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.Synonyms: DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125

Gen-ID: 7508

NCBI Accession: NP_001139241

Pathways: p53 Signalweg, DNA Reparatur