TGFB1 Antikörper

Produktnummer ABIN1109227

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TGFB1 in WB, FACS, IHC (p), EIA, IHC (fro) und Neut. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TGFB1 Antikörper (ABIN1109227)

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGFB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Neutralization (Neut)

Klon: TB21

Produktdetails anti-TGFB1 Antikörper

Spezifität: The antibody detects human TGF beta 1 (and has been used in sheep, see "Applications"). Other species not tested. In flow cytometry this antibody detects the intracellular form of TGF-beta (so-called latent, LAP-bound or inactive TGF-beta) as well as with membrane bound TGF-beta (extracellular matrix form). Western blotting demonstrated that this antibody reacts with the dimeric (25 kDa) and monomeric (12,5 kDa) forms of TGF-beta (active form) under both non-reducing and reducing conditions respectively. In ELISA the antibody recognizes both human platelet-derived and recombinant TGF-beta.

Aufreinigung: Affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Details zu TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Andere Bezeichnung: TGFB1

Hintergrund: Transforming Growth Factor-Beta (TGF-beta, TGFB) was originally identified for its ability to induce phenotypic transformation of fibroblasts in diverse cell types. This protein controls proliferation, differentiation, and many other functions of various cell types. TGFB is present on most cell types including T cells and monocytes.Synonyms: TGF-beta-1, TGFB, Transforming growth factor beta-1

Gen-ID: 7040

NCBI Accession: NP_000651

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie, Cancer Immune Checkpoints