LBP Antikörper

Produktnummer ABIN1108022

Der Maus-Monoklonal Anti-LBP-Antikörper wurde für IP, Func, ELISA (Capture) und ELISA (Detection) validiert. Er ist geeignet zum Nachweis von LBP in Proben aus Human. }

Kurzübersicht für LBP Antikörper (ABIN1108022)

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LBP Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Functional Studies (Func), ELISA (Capture), ELISA (Detection)

Klon: 1C7

Produktdetails anti-LBP Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, containing 0.02 % sodium, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu LBP

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Andere Bezeichnung: LBP

Hintergrund: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.Synonyms: Lipopolysaccharide-binding protein

NCBI Accession: NM_004139

UniProt: P18428

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process