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IFNA Antikörper

IFNA Reaktivität: Human Neut Wirt: Maus Monoclonal #14 unconjugated
Produktnummer ABIN1107768
  • Target Alle IFNA Antikörper anzeigen
    IFNA (Interferon alpha (IFNA))
    Reaktivität
    • 34
    • 24
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 66
    • 28
    • 4
    • 4
    • 1
    • 1
    Maus
    Klonalität
    • 72
    • 31
    Monoklonal
    Konjugat
    • 54
    • 14
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser IFNA Antikörper ist unkonjugiert
    Applikation
    • 97
    • 39
    • 32
    • 31
    • 26
    • 26
    • 21
    • 13
    • 13
    • 10
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Neutralization (Neut)
    Keine Kreuzreaktivität
    Maus
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Endotoxin-Niveau
    < 10 ng/mg of antibody, as determined by the LAL assay
    Immunogen
    Human IFN-alpha (purified)
    Klon
    #14
    Isotyp
    IgG1
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS without preservatives
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store (in aliquots) at -20 °C.
  • Target
    IFNA (Interferon alpha (IFNA))
    Andere Bezeichnung
    Interferon alpha (IFN Alpha) (IFNA Produkte)
    Synonyme
    IFN-alphaO antikoerper, IFN-ALPHA-1 antikoerper, IFN1@ antikoerper, Ifa antikoerper, Ifa8 antikoerper, interferon alpha 16 antikoerper, interferon, alpha 1 antikoerper, interferon alpha antikoerper, interferon-alpha antikoerper, IFNA16 antikoerper, IFNA1 antikoerper, Ifna antikoerper, IFNA antikoerper
    Hintergrund
    The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: B Cell Interferon, IFN-alpha, IFNA, Interferon-alpha, Leukocyte Interferon, Type I Interferon
    Pathways
    JAK-STAT Signalweg, TLR Signalweg, Hepatitis C, Inflammasome
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