IFNA Antikörper

Produktnummer ABIN1107768

Dieses Anti-IFNA-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IFNA in Neut. Geeignet für Human.

Kurzübersicht für IFNA Antikörper (ABIN1107768)

Target: IFNA (Interferon alpha (IFNA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IFNA Antikörper ist unkonjugiert

Applikation: Neutralization (Neut)

Klon: #14

Produktdetails anti-IFNA Antikörper

Keine Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Endotoxin-Niveau: < 10 ng/mg of antibody, as determined by the LAL assay

Immunogen: Human IFN-alpha (purified)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu IFNA

Target: IFNA (Interferon alpha (IFNA))

Andere Bezeichnung: Interferon alpha (IFN Alpha)

Hintergrund: The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: B Cell Interferon, IFN-alpha, IFNA, Interferon-alpha, Leukocyte Interferon, Type I Interferon

Pathways: JAK-STAT Signalweg, TLR Signalweg, Hepatitis C, Inflammasome