anti-CLEC7A (CLEC7A) Antikörper

Pig (Porcine) C-Type Lectin Domain Family 7, Member A (CLEC7A) Interaktionspartner

1. These results suggest that functionally neutral polymorphisms in dectin-1 are widespread in pig populations

2. recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 (zeige ITGAM Antikörper) are involved in the beta-glucan-mediated responses in pig macrophages.

Mouse (Murine) C-Type Lectin Domain Family 7, Member A (CLEC7A) Interaktionspartner

1. These results identify dectin-1-activated dendritic cells as a powerful inducer of Th9 cells and antitumour immunity and may have important clinical implications.

2. These findings demonstrate that Dectin-1, Irak1 (zeige IRAK1 Antikörper), and Rip2 (zeige ARHGDIG Antikörper) are involved in response to Aspergillus fumigatus infection. Dectin-1 modulates the expression of Irak1 (zeige IRAK1 Antikörper) and Rip2 (zeige ARHGDIG Antikörper).

3. Feeding Guar gum fiber increases SOCS-1 (zeige SOCS1 Antikörper), TLR2 and dectin-1 expression in dextran sodium sulfate administered and normal mice.

4. Dectin-1 agonists selectively induce IgG1 class switching by direct stimulation of Dectin-1 on LPS (zeige TLR4 Antikörper)-activated B cells resulting in selective production of IgG1.

5. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.

6. this study shows the critical role of Dectin-1 for inflammasome activation, restriction of parasite replication in macrophages, and mouse resistance to Leishmania amazonensis infection in vivo

7. results demonstrate that Dectin-1-triggered Card9 (zeige CARD9 Antikörper) signaling but not inflammasome activation can potently cross-prime Ag-specific cytotoxic T-cells, suggesting that this pathway would be a candidate for immunotherapy and vaccine development

8. Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma (PDA). Clec7a deletion is protective against PDA, however Clec7a does not have direct protumorigenic effects on transformed pancreatic ductal epithelial cells.

9. Dectin-1 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.

10. these results suggest that Dectin-1 expressed on CD11b (zeige ITGAM Antikörper)(+) dendritic cells (DCs) senses some molecule(s) in house dust mite (HDM (zeige HDAC3 Antikörper)) extract and plays a critical role in the induction of HDM (zeige HDAC3 Antikörper)-induced allergic airway inflammation by inducing the expression of chemokine/chemokine (zeige CCL1 Antikörper) receptors in DCs.

Human C-Type Lectin Domain Family 7, Member A (CLEC7A) Interaktionspartner

1. Dectin-1 receptor blockage decreased the IL-12 (zeige IL12A Antikörper), IL-17 (zeige IL17A Antikörper), IL-10 (zeige IL10 Antikörper) and TNF-alpha (zeige TNF Antikörper) levels indicating the participation of such receptor in the induction of these cytokines.

2. Dectin-1 is expressed on mDCs and is down-regulated after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via this receptor. Blocking of Dectin-1, followed by stimulation with depleted zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40 (zeige CD40 Antikörper), CD80 (zeige CD80 Antikörper), HLA-DR and CCR7 (zeige CCR7 Antikörper) on mDCs and led to decreased release of the cytokines TNF-alpha (zeige TNF Antikörper), IL-8 (zeige IL8 Antikörper), IL-1beta (zeige IL1B Antikörper) and IL-10 (zeige IL10 Antikörper).

3. this study shows that Dectin-1 is essential for IL-1beta (zeige IL1B Antikörper) production through JNK (zeige MAPK8 Antikörper) activation and apoptosis in Aspergillus fumigatus keratitis

4. high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments

5. Dectin-1 may have therapeutic implications as a biomarker for metabolic dysregulation in humans.

6. theses data suggest miR (zeige MLXIP Antikörper)-146a may play the potent negative feedback regulator in inflammatory response following Dectin-1 stimulation

7. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.

8. Unique cytokine secretion and varying expression levels of n Dectin-1 isoforms on monocyte-derived cells may indicate distinct isoform usage as a cell type-specific mechanism of regulating anti-fungal immunity.

9. Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma.

10. Dectin-1-mediated activation of the Syk (zeige SYK Antikörper), MAPKs, PI3K (zeige PIK3CA Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) signaling pathways contributes to F. proliferatum-stimulated CXCL-8 (zeige IL8 Antikörper) release from BEAS-2B cells and provides an important basis for developing novel therapeutic strategies in clinical allergy.

Cow (Bovine) C-Type Lectin Domain Family 7, Member A (CLEC7A) Interaktionspartner

1. CLEC7a genetic variant c.589A>G was significantly associated (p = 0.008) with Mycobacterium avium ssp. paratuberculosis infection in Holsteins cattle.