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Dectin-1 and Dectin-2 cleavage by NE and/or A. fumigatus-derived proteases results in an aberrant antifungal immune response.
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mDectin-1, mDectin-2, and SIGN-R1 are decorated by N-glycan structures that can be recognized by the carbohydrate recognition domain of Gal-3.
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the ligand-induced cooperative oligomer formation of Dectin-1 is physiologically relevant in sensing exogenous beta-glucan and triggering intracellular signaling.
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Dectin-1expression was significantly upregulated in Fusarum solanum induced keratomycosis.
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Dectin-1 plays an important role in host defense against systemic Candida glabrata infections.
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These results identify dectin-1-activated dendritic cells as a powerful inducer of Th9 cells and antitumour immunity and may have important clinical implications.
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These findings demonstrate that Dectin-1, Irak1, and Rip2 are involved in response to Aspergillus fumigatus infection. Dectin-1 modulates the expression of Irak1 and Rip2.
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Feeding Guar gum fiber increases SOCS-1, TLR2 and dectin-1 expression in dextran sodium sulfate administered and normal mice.
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Dectin-1 agonists selectively induce IgG1 class switching by direct stimulation of Dectin-1 on LPS-activated B cells resulting in selective production of IgG1.
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These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.
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this study shows the critical role of Dectin-1 for inflammasome activation, restriction of parasite replication in macrophages, and mouse resistance to Leishmania amazonensis infection in vivo
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results demonstrate that Dectin-1-triggered Card9 signaling but not inflammasome activation can potently cross-prime Ag-specific cytotoxic T-cells, suggesting that this pathway would be a candidate for immunotherapy and vaccine development
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Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma (PDA). Clec7a deletion is protective against PDA, however Clec7a does not have direct protumorigenic effects on transformed pancreatic ductal epithelial cells.
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Dectin-1 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.
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these results suggest that Dectin-1 expressed on CD11b(+) dendritic cells (DCs) senses some molecule(s) in house dust mite (HDM) extract and plays a critical role in the induction of HDM-induced allergic airway inflammation by inducing the expression of chemokine/chemokine receptors in DCs.
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The sum of the data suggests that in contrast to IgG-based immune complexes boosting immune reactivity of antigen-presenting cells, secretory IgA produced during an ongoing immune response can, in addition to its known function of immune exclusion, modulate mucosal dendritic cell conditioning via specific interaction with Dectin-1 and SIGNR3.
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data suggest that the C-Type lectin receptor Dectin-1 is a major pattern recognition receptor that orchestrates miR155 upregulation in a Syk-dependent manner; results suggest that PRR-mediating signaling events are key drivers of miRNA-mediated gene regulation during fungal pathogenesis
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results strongly suggest that Ae2 is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 expression and fungal clearance is regulated.
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this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-1; in vivo, its deficiency compromises fungal clearance
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SCIMP is strongly phosphorylated after Dectin-1 stimulation and that it participates in signal transduction downstream of this important pattern recognition receptor.
