anti-phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Antikörper

Human phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Interaktionspartner

1. Protein adaptation and the expanding roles of the PACS1 (zeige PACS1 Antikörper) and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)

2. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.

3. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

4. Tumor necrosis factor (zeige TNF Antikörper)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.

5. subcellular localization and function of polycystin-2 (zeige PKD2 Antikörper) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 (zeige PACS1 Antikörper) and PACS-2

6. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

7. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (zeige TG Antikörper)/endosomal system

8. the phosphorylation state of the calnexin (zeige CANX Antikörper) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane

9. Results identify PACS-2 as an essential TRAIL effector, and show that Akt (zeige AKT1 Antikörper) cooperates with 14-3-3 (zeige YWHAQ Antikörper) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

Mouse (Murine) phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Interaktionspartner

1. PACS-2 coordinates p53 (zeige TP53 Antikörper)/p21 (zeige D4S234E Antikörper)- dependent cell cycle arrest with NF-kappaB (zeige NFKB1 Antikörper)/Bcl-xL (zeige BCL2L1 Antikörper)-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.

2. CS-2 (zeige MYOZ1 Antikörper) traffics to the nucleus where it regulates SIRT1 (zeige SIRT1 Antikörper)-mediated p53 (zeige TP53 Antikörper) deacetylation. PACS-2 binds SIRT1 (zeige SIRT1 Antikörper) in vitro and directly inhibits SIRT1 (zeige SIRT1 Antikörper)-catalyzed p53 (zeige TP53 Antikörper) deacetylation.

3. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (zeige TG Antikörper)/endosomal system

4. Results identify PACS-2 as an essential TRAIL effector, and show that Akt (zeige AKT1 Antikörper) cooperates with 14-3-3 (zeige YWHAQ Antikörper) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.