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VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Zusätzlich bieten wir Ihnen VTCN1 Antikörper (208) und VTCN1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.
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this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.
Ablation of B7-H3 (zeige CD276 Proteine) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (zeige CD8A Proteine) T cell-induced diabetes.
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.
The decrease of B7-H4 expression in salivary glands of Sjogren's syndrome patients contributes to the defect of negatively regulating the inflammation caused by CD4 (zeige CD4 Proteine)(+) T cells.
Preclinical investigation into B7-H4-specific chimeric antigen receptor (CAR) T cells, antibody-mediated blockade of B7-H4, and anti-B7-H4 drug conjugates has shown antitumor efficacy in mouse models.
This meta-analysis demonstrated that high B7-H4 expression is an unfavorable prognostic factor in NSCLC.
This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors.
in pulmonary adenocarcinoma presenting with SPN (zeige SPN Proteine), nuclear membrane localization of B7-H4 within the tumor cells is associated with increased malignancy
Study reportes that B7-H3 (zeige CD276 Proteine) and B7-H4 are highly expressed in human esophageal cancer tissues and significantly associated with tumor invasion.
Results revealed B7-H4 to be associated with poor prognosis in patients with pancreatic cancer liver metastasis. B7-H4 may promote pancreatic cancer metastasis.
PD-L1 (zeige CD274 Proteine), IDO-1 (zeige IDO1 Proteine), and B7-H4 are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 (zeige CD274 Proteine) and IDO-1 (zeige IDO1 Proteine) are associated with increased tumor-infiltrating lymphoycte and IFN-gamma (zeige IFNG Proteine) stimulation, B7-H4 is not.
B7-H4 activation on Mphis/microglia in the microenvironment of gliomas is an important immunosuppressive event blocking effective T-cell immune responses.
Knockdown of B7-H4 significantly up-regulated 57 miRNAs and down-regulated 14 miRNAs.
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
V-set domain-containing T-cell activation inhibitor 1
, V-set domain containing T cell activation inhibitor 1
, V-set domain containing T-cell activation inhibitor 1
, immune costimulatory protein B7-H4
, t cell costimulatory molecule B7x
, B7 family member, H4
, B7 superfamily member 1
, T cell costimulatory molecule B7x
, T-cell costimulatory molecule B7x